Furthermore, multivariable analysis identified both APE1 expression level (HR = 1.9; 95% CI = 1.3 - 2.9; p = 0.002) and clinical stage (HR = 2.4; 95% CI = 1.5 - 3.9; p < 0.001) as independent prognostic factors for ESCC in this TMA cohort (Figure 5B). The gene discussed is APEX1; the disease is esophageal squamous cell carcinoma.