Subsequent multivariate COX analysis demonstrated that both tumor APE1 expression (OS: HR = 2.7, 95% CI 1.9–4.0, p < 0.001; DFS: HR = 2.7, 95% CI 1.9 - 3.8, p = < 0.001 ) and tumor stage (OS: HR = 2.9, 95% CI 1.7–5.0, p < 0.001; DFS: HR = 3.1, 95% CI 1.8–5.2, p < 0.001 ) were independent prognostic factors for both OS and DFS (Figures 4F, G). This evidence concerns the gene APEX1 and neoplasm.