Simultaneously, using canonical markers, we annotated clusters into malignant states (MES2-like, MES1-like, NPC2-like, NPC1-like, AC-like, OPC-like, and a Proliferation-high group) and non-malignant lineages (T cells, TAM-microglia, endothelial, SMC, oligodendrocytes), which segregate in the embedding with tumor cells spanning an NPC/AC/OPC-to-MES continuum and proliferation overlaying multiple states (Figures 2C, D). The gene discussed is NPC2; the disease is neoplasm.