PFKFB3 and cancer: Cancer cells frequently upregulate glucose transporters and key enzymes in the glycolytic pathway, including Glucose transporter type 1 (GLUT1), Hexokinase 2 (HK2), 6-phosphofructokinase 2/fructose 2,6-bisphosphatase 3 (PFKFB3), pyruvate kinase muscle form 2 (PKM2) and lactate dehydrogenase A (LDHA) (86).