Although inhibition of PFKFB3 has also been demonstrated to reduce cancer cell proliferation, the concentrations of the PFKFB3 inhibitor 3-(pyridin-3-yl)-1-(pyridin-4-yl)prop-2-en-1-one (3PO) required to achieve this effect were shown to simultaneously reduce vessel integrity and facilitate metastasis (191–193). This evidence concerns the gene PFKFB3 and cancer.