IGHE and Erythema: Moreover, myricetin can also effectively alleviates erythema, edema, pruritus, and epidermal thickening by suppressing proinflammatory cytokines, modulating Th1/Th2/Th17 immune balance, inhibiting MCs infiltration and the release of histamine and IgE, and restoring skin barrier function through the inhibition of NF-κB and STAT1 signaling pathways in vivo/in vitro (201, 202).