Evidence from both clinical samples and animal models indicates that MRGPRX2 in humans and its murine ortholog MrgprB2 are positively correlated with inflammation severity (35), contribute to sensory neuron activation and scratching behavior (154), and mediate non-IgE-dependent inflammatory responses in AD models (155), highlighting their potential as functional therapeutic targets. The gene discussed is MRGPRX2; the disease is Alzheimer disease.