↓pruritus (rapid & sustained), ↓EASI, ↑EASI-75, ↑IGA success, ↓sleep disturbance, ↓DLQI, ↓proinflammatory biomarkers (CCL20, CCL22, CCL27, VEGF); well tolerated with mainly injection-site reactions and nasopharyngitis. The gene discussed is VEGFA; the disease is nasopharyngitis.