PPARGC1A and Anxiety: The efficacy of resveratrol in our study is supported by findings from Tabassum et al. (Tabassum et al., 2023), who demonstrated in a chronic unpredictable mild stress model that resveratrol reversed anxiety and depressive-like behaviors through the SIRT1/PGC1α/SIRT3 signaling pathway in the medial prefrontal cortex.