Several polysaccharides, including Cantharellus cibarius polysaccharide, Dendrobium officinale polysaccharide, and Cordyceps mili-taris polysaccharide, have been shown to polarize TAMs toward the M1 phenotype by binding to the target receptor TLR2, thereby inhibiting multiple tumor growth processes (Bi et al., 2020; Meng et al., 2019; Wang H. Y. et al., 2022). The gene discussed is TLR2; the disease is neoplasm.