Ya-Rui Hou et al. found that lncRNA Dio3os was downregulated in HCC and that it could bind to NONO protein and inhibit zinc finger box binding homology box 1 (ZEB1) from the nucleus, which significantly inhibited tumour progression through its inhibitory effect in HCC hepatocytes [16]. The gene discussed is NONO; the disease is hepatocellular carcinoma.