We describe two cases. Case 1 is a 27-year-old woman with genetically confirmed classic 11βOHD (homozygous CYP11B1 splice-site variant c.240-2A>G), initially misdiagnosed as 21-hydroxylase deficiency, who achieved spontaneous conception despite high androgen levels, long-term steroid exposure, and prior genital surgery and delivered a healthy male child. The gene discussed is CYP11B1; the disease is classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency.