In preclinical studies, various doses of AAV5-hNR2E3 administered during the early to intermediate stages of retinal degeneration in rd7 or RhoP23H+/− mice models restored homeostasis by resetting key Nr2e3-associated pathways, and resulted in improved photoreceptor survival and function (35, 36). The gene discussed is NR2E3; the disease is retinal degeneration.