The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) aimed to determine whether a CCB (amlodipine) or an ACE inhibitor (lisinopril) lowers coronary heart disease (CHD) or other cardiovascular events compared with a thiazide-like diuretic (chlorthalidone). The gene discussed is ACE; the disease is coronary artery disorder.