SPHK2 and neoplasm: Mechanistically, SphK2-generated S1P binds to human telomerase reverse transcriptase (hTERT) at the periphery of the nucleus, stabilizing telomerase activity via allosteric phosphorylation mimicry, thereby maintaining telomere length and promoting tumor growth, suggesting that targeting the SphK2/S1P-hTERT axis may be a novel anticancer strategy (49).