Ischaemic hepatitis (“shock liver”) affects up to 13.4% of ICU admissions (30, 31), and AST/ALT elevations may also stem from drug-induced liver injury (32) heart failure (33, 34), rhabdomyolysis (31), acute or chronic liver failure (31), or parenteral nutrition-associated liver disease (PNALD) (35). This evidence concerns the gene GPT and chronic liver failure.