Although beyond the scope of the current study to verify, we propose that the SD-Tg(ACE2)955CPBryd and SD-Tg(ACE2)058CVBryd lines might be consistent with typical infection in healthy adult humans, and that this model may be appropriate for understanding the impact of comorbidities or as a model of post-acute sequelae of COVID (PASC). This evidence concerns the gene ACE2 and infection.