A direct comparison between TEL::AML1 and BCR-ABL fusion gene groups (Table 5) revealed that BCR::ABL-positive patients had higher mean WBC counts (86.9 vs 43.6 × 109/L), higher LDH levels (2,287 vs 1,077 U/L), higher rates of hepatosplenomegaly (60% vs 30%) and higher frequencies of high-risk classification (60% vs 10%) than TEL::AML1-positive patients. Here, RUNX1 is linked to Hepatosplenomegaly.