SNHG3 and SNHG5 show relatively low expression in thyroid cancer and possess certain inhibitory effects, closely linked to their roles in autophagy regulation (the SNHG5–RBM47/USP21–FOXO3 axis) and modulation of AKT/mTOR/MAPK signaling pathways. The gene discussed is SNHG3; the disease is thyroid cancer.