For example, selective inhibition of CK1α using D4476 inhibits autophagy flux, potentially suppressed the proliferation and the metastasis of RAS-mutated human CRC HCT116 cells, EGFR-mutant Non-small cell lung cancer (NSCLC), and human multiple myeloma U-266 cells. The gene discussed is CSNK1A1; the disease is non-small cell lung carcinoma.