For example, hypoxic conditions in the tumor core inhibit TET DNA demethylases, leading to hypermethylation of pro-apoptotic genes (Yabo et al., 2022; Zhang et al., 2025); conversely, EZH2 overexpression in the invasive edge stabilizes a mesenchymal phenotype that enhances motility and radiation evasion (Kunadis et al., 2021; Li F. et al., 2021; Zhang et al., 2025). This evidence concerns the gene EZH2 and neoplasm.