Single-cell chromatin immunoprecipitation (scChIP-seq) of GBM surgical specimens reveals that invasive edge cells have 2.3-fold higher EZH2 expression and 1.9-fold higher H3K27me3 levels at differentiation gene promoters (e.g., OLIG2, SOX10) compared to core cells (Kim et al., 2024). This evidence concerns the gene EZH2 and glioblastoma.