Supporting this hypothesis, prior studies in patients with Alzheimer’s disease,24,25 found that texture analysis detected microstructural changes in grey matter earlier than volume-based measures,24,26 predicted the progression from mild cognitive impairment (MCI) to Alzheimer’s disease,27,28 and correlated with tau PET tracer binding,29 linking changes in texture to neuropathology. Here, MAPT is linked to Alzheimer disease.