MAPT and early-onset autosomal dominant Alzheimer disease: Supporting this hypothesis, prior studies in patients with Alzheimer’s disease,24,25 found that texture analysis detected microstructural changes in grey matter earlier than volume-based measures,24,26 predicted the progression from mild cognitive impairment (MCI) to Alzheimer’s disease,27,28 and correlated with tau PET tracer binding,29 linking changes in texture to neuropathology.