SP1 and Familial prostate cancer: Although several resistance mechanisms, including the prostate cancer gene expression marker 1 (PCGEM1)/miR-129-5p/ETS variant 1 (ETV1) and lysine-specific demethylase 1 (LSD1)/long intergenic non-protein coding RNA 1134 (LINC01134)/specificity protein 1 (SP1)/p62 pathways, have been identified recently, most investigations have been limited to in vitro studies.