A gene signature was identified with nine genes (RAMP1, LMX1B, GSG1L, HOXC13, CGA, ANKRD1, GRIK4, NRCAM e LRFN1) that suggests an association with neuronal pathway processes, influencing the tumor microenvironment and conferring therapeutic resistance, with particular emphasis on gene RAMP1. The gene discussed is LRFN1; the disease is neoplasm.