High expression of RAMP1, that encodes the receptor for protein activity-modifying protein 1 (a coreceptor for certain G protein-coupled receptors on the plasma membrane), is associated with poorer oncological outcomes in osteosarcoma, likely as a secondary effect of alterations in the tumor microenvironment (L. Xie et al., 2023). The gene discussed is RAMP1; the disease is neoplasm.