M2 macrophages are typically anti-inflammatory, characterized by a poor capacity to present antigens, which leads to immunosuppressive effects and promotes cell proliferation, tissue repair, angiogenesis, and the release of immunosuppressive molecules in the tumor microenvironment, such as IL-10, TGF-β, and HLA-G (Allavena et al., 2008; Komohara et al., 2016). Here, TGFB1 is linked to neoplasm.