Conversely, interleukin receptor SHC signaling, type I interferon induction and signaling during SARS−CoV−2 infection, caspase activation via extrinsic apoptotic pathways, binding of TCF/LEF ctnnb1 to target gene promoters, and runx3’s regulation of WNT signaling gene sets were significantly and highly enriched in PDR samples (Figure 3F, Supplementary Table S7). The gene discussed is SHC1; the disease is infection.