RUNX3 and infection: Conversely, interleukin receptor SHC signaling, type I interferon induction and signaling during SARS−CoV−2 infection, caspase activation via extrinsic apoptotic pathways, binding of TCF/LEF ctnnb1 to target gene promoters, and runx3’s regulation of WNT signaling gene sets were significantly and highly enriched in PDR samples (Figure 3F, Supplementary Table S7).