found that stress contributed to the development of Cushing’s syndrome of pituitary aetiology, while it did not affect the Cushing’s syndrome of independent pituitary origin (primary adrenal hyperfunction and ectopic ACTH production), which supports the hypothesis of the involvement of the limbic-hypothalamic system in the pathogenesis of this condition (43). The gene discussed is POMC; the disease is Cushing syndrome due to macronodular adrenal hyperplasia.