After the IGF-I levels were taken into account in the calculation of the total AL index, the value of the aforementioned index was found to be significantly higher in both the patients in the entire study group [8.00 (5.00–10.00) vs. 4.00 (2.00–5.00), M-W test: p < 0.001] and the patients with acromegaly [7.50 (5.00–9.25) vs. 4.00 (2.00–5.00), M-W test: p < 0.001], compared to the control group. This evidence concerns the gene IGF1 and acromegaly.