In mice with DN, ER stress induction was particularly observed in injured nociceptors.19 Although the roles of Bcl-XL in neuroprotection and of PERK signaling in ER stress have been widely addressed in epidemiologic studies on diabetes, no study has examined their coexpression profiles within the same cell, particularly in sensory nociceptors. This evidence concerns the gene EIF2AK3 and diabetes mellitus.