UBQLN2 and amyotrophic lateral sclerosis: The amyotrophic lateral sclerosis-associated UBQLN2 variants P497H, which has a minor effect on PEG10 abundance, and P506T, which has a more significant effect on PEG10 abundance (Black et al., 2023), did not completely abolish the interaction with PEG10 (Fig. S5C), although it remains possible there are minor changes to affinity that are not readily apparent in these tests.