INS and gestational diabetes: By week 15 of gestation, increased insulin values can already be detected in amniotic fluid of GDM-Pregnancies [22] Later on, increased fetal growth as a result of maternal hyperglycemia can be observed [23] Additionally, the results of the HAPO-Follow up study (HAPO-FUS) suggest hyperglycemia exerting an even greater influence on the long-term metabolic health of children than previously understood.