Concerning ATC, FAP has been suggested to play a significant role in immune escape strategies [12–14], such as downregulation of human leukocyte antigen class I (HLA-I) antigens [15] and an upregulation of immune checkpoint (ICP) molecules, e.g., the programmed death ligand 1 (PD-L1, CD274), known for its role in dampening anti-tumor immune responses [16, 17]. The gene discussed is FAP; the disease is neoplasm.