To translate the in vitro data into clinical application, a TMA of a TC cohort (n = 187 cases) consisting of 20 ATC, 18 PDTC, 84 PTC, 36 MTC and 29 FTC was analyzed by IHC for the expression of key ECM molecules, PD-L1, HLA-I HC and immune cell infiltration. Here, CD274 is linked to medullary thyroid gland carcinoma.