We established a signature comprising 15 genes associated with mechanical stimuli (ALDH3A1, CCL19, CDH19, CEACAM5, CPLX2, CWH43, CXCL1, FABP7, JCHAIN, KIAA0319, KRT15, PIGR, SPIB, TCN1, TEX19) and demonstrated its predictive capability for overall survival in breast cancer patients. The gene discussed is CPLX2; the disease is breast cancer.