We established a signature comprising 15 genes associated with mechanical stimuli (ALDH3A1, CCL19, CDH19, CEACAM5, CPLX2, CWH43, CXCL1, FABP7, JCHAIN, KIAA0319, KRT15, PIGR, SPIB, TCN1, TEX19) and demonstrated its predictive capability for overall survival in breast cancer patients. This evidence concerns the gene ALDH3A1 and breast cancer.