Through the application of LASSO Cox regression analysis in breast cancer cases, 15 pivotal genes were kept to establish the prognostic signature (ALDH3A1, CCL19, CDH19, CEACAM5, CPLX2, CWH43, CXCL1, FABP7, JCHAIN, KIAA0319, KRT15, PIGR, SPIB, TCN1, TEX19) and highlighted on the volcano plot (Fig. 4A-B, Supplementary Fig. 1). This evidence concerns the gene CPLX2 and breast cancer.