We established a signature comprising 15 genes associated with mechanical stimuli (ALDH3A1, CCL19, CDH19, CEACAM5, CPLX2, CWH43, CXCL1, FABP7, JCHAIN, KIAA0319, KRT15, PIGR, SPIB, TCN1, TEX19) and demonstrated its predictive capability for overall survival in breast cancer patients. Here, KRT15 is linked to breast cancer.