A recent study identified a conserved four-amino acid (NPGF) intracellular motif in VISTA that interacts with NUMB and sequesters it at endosomes, impairing epidermal growth factor receptor (EGFR) signaling and cellular proliferation in triple-negative breast cancer (TNBC) [203]. The gene discussed is EGFR; the disease is triple-negative breast carcinoma.