For example, the cancer-associated fibroblast regulator NNMT (Eckert et al, 2019), CD163, a marker of tumor-associated macrophages (TAMs) (Lecker et al, 2021), and oncogenic proteoglycan VCAN (Cheon et al, 2014) were significantly upregulated from the NFT stroma to the invasive stroma (Fig. 2I). This evidence concerns the gene VCAN and cancer.