NNMT and cancer: For example, the cancer-associated fibroblast regulator NNMT (Eckert et al, 2019), CD163, a marker of tumor-associated macrophages (TAMs) (Lecker et al, 2021), and oncogenic proteoglycan VCAN (Cheon et al, 2014) were significantly upregulated from the NFT stroma to the invasive stroma (Fig. 2I).