Analysis of TCGA data revealed significant co-expression patterns between MET and 14 key thyroid functional genes (including PAX8, TG, TPO, TSHR, NKX2-1, SLC5A5, SLC5A8, SLC26A4, FOXE1, THRA, DUOX1, DUOX2, DIO1, DIO2), while demonstrating a negative correlation with THRB. These genes are involved in iodine metabolism and thyroid-specific transcription, implicating MET in the regulation of thyroid cancer differentiation. This evidence concerns the gene PAX8 and thyroid cancer.