This approach allowed us to combine the risk factor associated with Pg LPS with a key environmental factor of dysmetabolism in the study of the worsening of glucose intolerance induced by the HFD in the presence or absence of LPS from Pg. Additionally, we evaluated the relevance of LPS from Pg in immune cell recruitment, particularly to establish its role in the context of T2D. Here, JUP is linked to type 2 diabetes mellitus.