Using a unique mouse model of endodontic Pg monocolonization combined with a HFD, the mice colonized with wild-type Pg (with its LPS) exhibited enlarged periapical lesions, increased infiltration of CD45+, CD19+, and Th17+ cells in lymphoid organs, and elevated expression of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, IL-10, TGF-β1) in adipose tissue, leading to impaired fasting glucose and glucose intolerance. Here, TNF is linked to Glucose intolerance.