The finding that Zeb, Snail and Tgfbeta are more effective drivers of EMT than Twist may be explained by the lower betweenness centrality of Twist1/2 in the network model, and comports with some experimental evidence: in cancer, Twist is associated with collective invasion, and depends on upstream activation of TGF-B to ensure complete EMT25. This evidence concerns the gene TWIST1 and cancer.