Additionally, we observed a significant decrease in insulin signaling in the liver cancer cell line HepG2 following knockdown of DNAJA2 (SiDJ2) (Fig. 2F, G), and this effect was consistent when DNAJA2 was knocked out in the mouse syngeneic cancer cell lines 4T1 and MC38 (Supplementary Fig. 3A–C). Here, INS is linked to cancer.