In a study on sepsis-induced acute kidney injury, GAS6 exerted protective effects through reducing renal tissue apoptosis, and suppressing inflammation and oxidative stress by inhibiting the downstream mediators such as nuclear factor-kappa B (NF-κB) [25], taking into consideration that targeting of the NF-κB pathway had renoprotective effects [26]. This evidence concerns the gene NFKB1 and acute kidney injury.