In addition, genome-wide association study and other studies have shown that the genetic variant of SLC39A8, rs13107325 (A391T), is associated with numerous pathological conditions, such as schizophrenia, Crohn's disease, scoliosis, and obesity, many of which are reported to be the result of defective Mn2+ homeostasis (18, 23, 26, 27, 28, 29, 30, 31, 32). The gene discussed is SLC39A8; the disease is obesity due to melanocortin 4 receptor deficiency.