In addition, genome-wide association study and other studies have shown that the genetic variant of SLC39A8, rs13107325 (A391T), is associated with numerous pathological conditions, such as schizophrenia, Crohn's disease, scoliosis, and obesity, many of which are reported to be the result of defective Mn2+ homeostasis (18, 23, 26, 27, 28, 29, 30, 31, 32). This evidence concerns the gene SLC39A8 and Crohn disease.