For example, a patient aged < 60-years (0-points), with ISS stage III (73.5-points), ECOG score < 2 (0-points), anemia (72.0-points), neutropenia (79.5-points), and albumin levels ≥ 35 g/L would have a total score of 290.5 points. The gene discussed is ALB; the disease is Decreased total neutrophil count.