ASCL1 and adenocarcinoma: Further examination revealed that ENZ treatment induced the expression of NR1D1/REV-ERBα and LP drivers, such as BRN2, ASCL1, FOXA2, and ONECUT2, in a dose and time-dependent manner in adenocarcinoma cells, with REV-ERBα being the fastest and strongest induced among them (Fig. 1 C and D and SI Appendix, Fig. S1 A–C).