TF motif analysis of ATAC-seq peaks induced by ENZ treatment or in NEPC cells revealed that REV-RE-like, half-site motif (CA/CA/GAGGTCA) that we previously identified in prostate cancer (39) was enriched in hyperaccessible chromatin regions in ENZR cells and post–ENZ treatment (Fig. 1F and SI Appendix, Fig. S1J). Here, TF is linked to Familial prostate cancer.