Dysregulations of TOLLIP gene, particularly genetic polymorphisms have been reported in susceptibility to and progression of distinct chronic infectious and fibrotic diseases, including Tuberculosis [68], malaria [69], Leprosy disease [70,71], visceral leishmaniasis [72], cutaneous (cuticle layer) leishmaniasis [24], and idiopathic pulmonary fibrosis lung disease (IPF) [73]. Here, TOLLIP is linked to leishmaniasis.