Several genetic polymorphisms of the TOLLIP gene have been reported to be associated as a risk factor in the progression of many diseases, such as cutaneous leishmaniasis [24], visceral leishmaniasis [25], leprosy [26], HIV infection, inflammation [27], tuberculosis [28], malaria [29], sepsis [30], Idiopathic Pulmonary Fibrosis (IPF) [31], and Atopic dermatitis (AD) [32]. This evidence concerns the gene TOLLIP and visceral leishmaniasis.