E2F1 and hepatocellular carcinoma: In fact, the first significant altered hallmark was hepatoblastoma [79] that was the most common pediatric liver cancer followed by other genes signature altered in hepatocellular carcinoma (HCC) such as SU_LIVER, LEE_LIVER_CANCER_E2F1_DN, LEE_LIVER_CANCER_MYC_E2F1_DN