This system is especially relevant for conditions involving mitochondrial dysfunction or redox imbalance, such as Leigh syndrome or cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder, where impaired OXPHOS, altered mitochondrial dynamics, and increased glycolytic reliance have been documented [12, 86, 87]. Here, CDKL5 is linked to CDKL5 disorder.