Interestingly, the maximum tolerated dose in the leukemia study (210 mg/kg) resulted in ~ 0.9mM concentration in whole blood after 4 h of infusion, which is nearly twice the concentration of AICAr used in our study to inhibit autophagy and induce p62/NRF2 in cardiomyocytes. The gene discussed is SQSTM1; the disease is leukemia.