The application of spatial transcriptomics and single-cell epigenomic profiling would help capture the dynamic and heterogeneous regulation of ThPOK, particularly in processes like the ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC) transition, where spatial context and cellular heterogeneity are critical. This evidence concerns the gene ZBTB7B and ductal breast carcinoma in situ.