Another patient with a tumor harboring RAD51C (copy-number loss), PIK3R1 (c1986-2A>G), TP53 (p.P278R), SMAD4 (pC363Y), PTEN (copy-number loss), TMPRSS2-ERG, and MYC copy-number gain had marked improvement of bone metastases, PSA response, and SD per RECIST. This evidence concerns the gene SMAD4 and neoplasm.