Epithelial-specific disruption of Cdh1 led to E-cadherin loss (Fig. 6 B), but, astonishingly, did not result in cleft lip, and E12.5 Cdh1f/f; CrectTg/0 mutant embryos were indistinguishable from littermate controls (Fig. 5 B). This evidence concerns the gene CDH1 and cleft lip.