Beyond craniofacial development, we were surprised to observe that E12.5 Ctnnd1Y112E/Y112E, Ctnnd1S288A/S288A, and Ctnnd1K622A,K623A/K622A,K623A homozygous mutants also did not exhibit cleft lip and were viable and healthy as adult mice (Fig. S3, A–C), indicating that these interaction domains are not absolutely required for the many crucial in vivo functions of p120-catenin. Here, CTNND1 is linked to cleft lip.