CDH1 and cleft lip: Notably, in humans, numerous mutations in genes encoding proteins of the adherens junction complex, including core components such as E-CADHERIN (CDH1) and P120-CATENIN (CTNND1), have been implicated in causing cleft lip as part of blepharocheilodontic syndrome and non-syndromic cleft lip (Kievit et al., 2018; Cox et al., 2018).