ZBTB33 and cancer: As Ctnnd1S288A/S288A mice also did not exhibit developmental phenotypes, we conclude that Kaiso regulation is likely dispensable for development, though a role of this regulatory modality in cancer cannot be ruled out (Zhang et al., 2011; Mayerle et al., 2003; Vermeulen et al., 2012; Thoreson and Reynolds, 2002).