TLR4 and acute myeloid leukemia: In the AML U937 cell line, FA upregulates the expression of Bax and Caspase‐3 while downregulating CyclinD1, CyclinE, Bcl‐2, TLR4, and NF‐κB mRNA levels via modulation of the TLR4/NF‐κB signaling pathway, thereby promoting apoptosis [29].