Research has shown that in DLBCL cells, matrine shortens the half‐life of c‐Myc protein (from 30.4 and 69.4 min to 16.6 and 15.9 min, respectively) by regulating the CaMKIIγ/c‐Myc/CDK6 axis. This evidence concerns the gene MYC and diffuse large B-cell lymphoma.