Looking at the history of VN tolerability through the lens of SRV, it is noteworthy that the preclinical VN studies in RPE65−/− Briard dogs40,41 and NHPs42 in which no retinal thinning and atrophy were reported used smaller SRVs of 100-200 μL, compared to a larger SRV of 300 μL in human patients.43 The gene discussed is RPE65; the disease is Atrophy.