Serum PIVKA‐II was positively correlated with AFP, ALT, AST, ALP, and GGT in patients with HCC (r = 0.187, p = 0.004; r = 0.201, p = 0.002; r = 0.237, p < 0.001; r = 0.293, p < 0.001; and r = 0.364, p < 0.001, respectively), but not with PT, INR, and APTT (r = 0.029, p = 0.651; r = 0.019, p = 0.771; and r = 0.090, p = 0.162, respectively) (Table S3, Figure 2). Here, AFP is linked to hepatocellular carcinoma.