Hepatic steatosis detected either by imaging (with ultrasound or controlled attenuated parameter), blood biomarkers (ALT), or liver histology,AND•Excess adiposity based on BMI SDS or waist circumference percentile, OR•Prediabetes or type 2 diabetes, OR•At least two metabolic risk abnormalities based on blood pressure, plasma triglycerides, plasma HDL cholesterol, and triglycerides-to-HDL-ratio. The gene discussed is GPT; the disease is type 2 diabetes mellitus.