Similarly, CircANKS1B promotes breast cancer invasion and metastasis by sequestering miR-148a-3p and miR-152-3p, leading to the upregulation of the transcription factor USF1 and a subsequent increase in TGF-β1 expression, ultimately activating the TGF-β1/SMAD signaling cascade to induce EMT [35]. This evidence concerns the gene TGFB1 and breast cancer.