CD8A and non-small cell lung carcinoma: The response group exhibited a comparable trend of changes in NCIT as the overall NSCLC patients, with significant increases in the density of CD8+ T cells [28 (22.44) vs. 7 (4.22), p = 0.020], CD8+ Trm-dys [5 (2.7) vs. 0 (0.1), p = 0.001], CD8+ Tbys [18 (13.25) vs. 3 (1.10), p = 0.003], CD8+ Tbys-cyt [15 (10.20) vs. 2 (1.10), p = 0.003], and CD8+ Tbys-dys [2 (0.4) vs. 0 (0.0), p < 0.001] had reduced densities, whereas CD4+ T cells [278 (200,374) vs. 432 (376,603), p = 0.002], CD4+ Tcon [258 (162,331) vs. 409 (366,561), p = 0.001] had significantly higher densities (Supplementary Table 2).